StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...
Free

Tissue Engineering - Essay Example

Cite this document
Summary
This paper 'Tissue Engineering' tells us that the initial consideration of any scaffold for TE is biocompatibility; cells must stick, function normally and move onto the surface and finally through the Scaffold and begin the proliferation process before producing a new matrix (Robert, 2013)…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER91.8% of users find it useful
Tissue Engineering
Read Text Preview

Extract of sample "Tissue Engineering"

  • Biodegradability: Since TE intends to facilitate the body’s cells to eventually replace the implanted tissue-engineered structure over time, scaffolds are not intended to be permanent implants. Thus, Scaff old needs to be biodegradable to allow cells to generate then extra-cellular matrix (Robert, 2013).
  • Mechanical property: Relatively strong properties may be needed in cases where the devices may be subjected to weight-loading whereas in another case, relatively less strong properties may be required.

Cells

The key consideration should be the source of the cells. Cells are categorized by their sources. For instance, autologous cells are obtained from the same individual to which they need to be re-implanted; Allogenic cells are got from the body of the donor of the same species while xenogeneic cells are from individuals of another species (Robert, 2013). During cells selection, cells leading to the fewest problems with rejection and pathogen transmission are preferred (mostly autologous). However, autologous cells cannot be obtained if the individual affected is elderly or has suffered severe burns.

Biomaterials

  • Biocompatibility: The initial consideration of any biomaterial for TE is biocompatibility; cells must stick, function normally, and move onto the surface and finally through the biomaterial and begin the proliferation process before producing a new matrix. Biomaterial construct must show a negligible immune reaction after implantation to prevent rejection by the body
  • Injectability: TE tissues require a precisely designed combination of cells and a specialized scaffold support system, Injectable biomaterials, especially those delivered in aqueous solution are ideal delivery vehicles for both the cells and bioactive factors (Robert, 2013).
  • Another consideration for biomaterial should also be resorption rates, concentration, and transparency.

 

  1. When designing a template for repairing a damaged bone, I will ensure that the template is biodegradable, bioresorbable, three-dimensional; which provides mechanical strength to the bone while at the same time providing a guide for regeneration of bone tissue (Robert. 2013). Thus the template will be of biodegradable materials such as poly (L-lactic acid) and has the capacity of being guaranteed porous.

A pore-performing component is mixed with a continuous matrix formed of biodegradable material. The degradation rate of the pore-performing component should be higher than that of the matrix. Differential dissolution/biodegradation provides porosity to the template (Robert, 2013).

Critical considerations for the design of TEMPs for repairing damaged tissue include:

 

  • Biocompatibility
  • The Architecture of the template
  • Mechanical properties
  • Biodegradability
  1. The most difficult organ to duplicate via TE is the kidney (Robert, 2013). Kidney has multiple cell types and complex functional anatomy thus making it difficult to reconstruct. This is because obtaining compatible cells and scaffolds is rendered difficult due to the multiple cells and complex anatomy. Thus, most of the cells and scaffolds are rejected by the recipient leading to adverse health problems.

To develop a template for kidneys, I will use immunosuppressive drugs to prevent rejection and health problems thereof.

  1.  
  2. Can Tissue Engineers use 3D molds to create organs?

Tissue engineers have harnessed the power of stem cells by coming up with 3-D plastic molds known as scaffolds/matrices that resemble organs/body parts. A matrix is squirted by a soup of nutrients causing stem cells to grow into a hunk of tissue that can later be transplanted into a patient.

  1. Can optimal cell sources and scaffold-cell interactions be engineered for heart valves?

Outline to finding the answer:

  • Get the base valve cells to work with
  • Put altered valve cells into a scaffold to incubate the cells
  • Put the newly created valve cells to use
  • Track the progress.
  1. a). The volume of the graft will have a volume of 3 by 2 by 1 which is equal to 6cm3 and 6000mm3. Taking 10000 cells per cubic millimeter, the number of cells will be 6 x 10^9

b). If 112 hours results in generates 0^5 cells, starting from time 0, then starting with n number of cells will take how long to generate k number of cells?

The number of cells per hour will (4.25 x 10^5)/112=3795 per hour.

Thus, if starting number of cells is n and you want to end with k cells, the time taken will be given by (k – n)/3795.

c). the time taken will be given by [ (6 x 10^9) - ( 6 x 10^9 x 0.5)]/3795=790513

Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Midterm Essay Example | Topics and Well Written Essays - 500 words - 11”, n.d.)
Midterm Essay Example | Topics and Well Written Essays - 500 words - 11. Retrieved from https://studentshare.org/miscellaneous/1689545-midterm
(Midterm Essay Example | Topics and Well Written Essays - 500 Words - 11)
Midterm Essay Example | Topics and Well Written Essays - 500 Words - 11. https://studentshare.org/miscellaneous/1689545-midterm.
“Midterm Essay Example | Topics and Well Written Essays - 500 Words - 11”, n.d. https://studentshare.org/miscellaneous/1689545-midterm.
  • Cited: 0 times

CHECK THESE SAMPLES OF Tissue Engineering

Twenty years of Tissue Engineering Heart Valves: More Hype than Hope

The 21st century has seen a great deal in the field of biological sciences, which has redefined progress and revolutionised the manner in which products are engineered, as specifically observed in cases of Tissue Engineering and medical implants.... Tissue Engineering, a concept that is still developing, broadly encompasses the creation of biological agents and the remodelling of specific body tissues or organs, in order to substitute, restore, regenerate or improve their functional effectiveness (Nerem and Ensley, 2004)....
11 Pages (2750 words) Essay

Tissue Engineering and Regenerative Medicine

Research Proposal Artificial Organic Heart – Treating Cardiovascular Diseases through Tissue Engineering and Regenerative Medicine By Your name University Affiliations Date Artificial Organic Heart – Treating Cardiovascular Diseases through Tissue Engineering and Regenerative Medicine Cardiovascular diseases and heart failure are the major ailments plaguing millions of humans worldwide.... The gravity of this situation has led to unrelenting research on stem cells, Tissue Engineering, and regenerative medicine, which are promising and hopeful alternatives to organ transplants....
3 Pages (750 words) Essay

Bone Tissue Engineering

Nishi, Matsumoto, Dong and Uemura provide a clear conceptual framework by beginning with a brief introduction pertaining to the bone Tissue Engineering technology.... l bone Tissue Engineering is regarded as the perfect alternative for bone grafting.... This is mainly because contrary to grafting, bone Tissue Engineering provides the advantage of being able to produce a specific shaped, as well as size capable of matching any bone defect.... Nishi, Matsumoto, Dong and Uemura provide a clear conceptual framework by beginning with a brief introduction pertaining to the bone Tissue Engineering technology....
5 Pages (1250 words) Book Report/Review

3. Biomaterials for bone tissue-engineering

Osteoconductive cells support the growth of bones and also encourage Running Head: BIOMATERIALS FOR BONE Tissue Engineering Biomaterials for Bone Tissue Engineering Submitted by Goes Here September, 2011Biomaterials for Bone Tissue EngineeringProperties of BiomaterialsIn the past scientists wanted the materials implanted to be ‘bio-inert'; however these day they want these materials to be bioactive.... Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends....
2 Pages (500 words) Essay

What does the future hold for stem cells in relation to tissue engineering

In particular, the specific type and nature of the substrate that acts as the “culture” for these cells to lie in, as well as its innate stiffness The Future of Stem Cells in Tissue Engineering THE FUTURE OF STEM CELLS IN Tissue Engineering Stem cells can be defined as undifferentiated cells with the capacity of self-renewal, proliferation, and differentiation to become particular phenotypes (Pavlovic & Bálint, 2013: p6).... Stem cells possess immense potential in the field of Tissue Engineering....
2 Pages (500 words) Essay

Colon Cancer in Tissue Engineering

The author of this review "Colon Cancer in Tissue Engineering" touches upon the advances in the medical field.... Their innovation has led to Tissue Engineering (TE), which is the initiation of the regeneration of organs and tissues by taking advantage of the individual's self-healing capability 5.... Normally, Tissue Engineering purposes to control cells to trigger the regrowth of the respective tissue 6.... The reason being that reconstructive surgery does not replace the biological functioning of an organ or tissue 4....
4 Pages (1000 words) Literature review

Cardiac Tissue Engineering

The author analyzes the 'Mending Broken Hearts with Tissue Engineering' article which describes a novel scaffold for seeding stem cells and heart cells.... The article presents results in the new field of cardiac Tissue Engineering that seeks to revolutionize the treatment of end-stage heart failure.... Tissue Engineering employs biological, engineering, and material sciences to replace and improve the function of biological tissues.... 'application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationship in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve functions' (as quoted in Eschenhagen & Zimmermann, 2005)....
10 Pages (2500 words) Term Paper

Tissue Engineering and Artificial Organs

This work called "Tissue Engineering and Artificial Organs" focuses on the process of developing substitutes of biological content that help in the restoration, improvement, and maintenance of the tissues or the whole organ.... According to studies, Tissue Engineering attaches to four main aspects that relate to cells, growth factors that relate to the development of cells, scaffolds, and the whole environment, and its mechanical relations.... orous scaffolds provide the functions of a pathway that aids the Tissue Engineering process....
7 Pages (1750 words) Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us