Psychologists came up with a theory to define why neurotic creativity and unhappiness go hand-in-hand. Some of them argued that a part of the brain is useful for self-generated thought and active in neuroticism. This in turn yields both positive and negative traits.  Individuals who have negative feelings and thoughts, more likely will experience psychiatric disorders in their lifetime. Such people also tend to struggle with dangerous jobs (Kolodziej, 2015).

A psychologist known as Jeffrey Gray came up with research to identify why such people have an increased rate of susceptibility to threat. He came up to a conclusion after experimenting rodents  for a period how antianxiety drugs helped them relax and reduce sensitivity at the same time liven up the psychiatric patients. However, his observation did not account for the full spectrum for the neuroticism. It was also difficult to come up with an explanation for the neuroticism in terms of the magnified threat perception.  This is because, in most of the circumstances, the high scorers feel unhappy when there is no threat at all (Kolodziej, 2015).

Smallwood, one of the most renowned researcher, described a research that he had done. His research showed that individuals, who are at rest in the MRI scanner, have particularly negative thoughts. The research was evident in the regions of medical prefrontal cortex thatare associated with the perception of threat. Perkin one of the researchers in the medical field also identified that the activity of the brain circuits usually governs the self-generated thought that could be an explanation for neuroticism. Additionally, Dean Mobbs an expert on the neural basis showed that there is a switch from anxiety that is related to the forebrain activity.  Also, to the panic-related midbrain activity as the stimulus for threat moves closer (Kolodziej, 2015).