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Biological Importance of Metal Complexes of Pyrimidine-2-Thione - Research Paper Example

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In the paper “Biological importance of metal complexes of pyrimidine-2-thione” the author examines 2-Mercaptopyrimidine nucleotides, which are present in the RNA of Escherichia Coli and the tRNA of yeast. 2-Mercaptopyrimidine nucleotides have been shown to inhibit tRNA synthesis…
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Biological Importance of Metal Complexes of Pyrimidine-2-Thione
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Biological importance of metal complexes of pyrimidine-2-thione Introduction 2-Mercaptopyrimidine nucleotides are present in the RNA of Escherichia Coli and the tRNA of yeast (Krebs, 1996). 2-Mercaptopyrimidine nucleotides have been shown to inhibit tRNA synthesis (Cotton et al, 1999), thus working as antitumor agent or antihyroid agent (Hadjikakou, 2000). Similar inhibitory effect has also been seen in pyrimidine-2-thione and its derivatives (Jones & Katritzyky, 1958). Pyrimidine-2-thione also illustrates increased vitro bacteriostatic action (Moranet et al 2002). The pyrimidine-2-thione metal complexes, or its hydroxyl derivatives and pyrimidine-2-thiol tautomeric type has been analyzed for representative ligands (Wang et al, 2007). These complexes illustrate rich structural chemistry, biological properties or thermal and magnetic properties (Connely et al, 2005). On the contrary, the coordination chemistry of in ligands of 2-mercaptopyrimidine moiety (Jensen, 2008), which has amino and hydroxyl substituents around the pyrimidine ring is entirely unknown (Michele, 2010). The above figure illustrates the structural formulae (Dorothy, 1996). The formulae is of pyrimidine-2-thione (I) and some derivatives; amino and hydroxyl in tautomeric forms (Erick, 2009). The first series metals entail zinc, iron, scandium, copper, chromium, iron, nickel and cobalt. These transition metals entail atoms which have atoms with incomplete d sub shell. Also the metals entails metals with atoms that produce cations that have incomplete d sub shell. Preparation of the Complexes Mo205L2(H2O)2.H2O (1)preparation. (5cm3)Aqueous solution of (NH4)2(MoO4) which is 0.24g and 1.0mmol respectively is added to LH solution in 25cm3 of EtOH (Speziale, 1963). The resultant slurry is subjected to heat, and the resultant solution, orange in color, is refluxed for duration of 4hours (Harris & Bertolucci, 1989). In this time duration, orange precipitate is realized (Foster & Snyder, 1963). The solid is then collected through filtration, immediately thereafter washed in 2cm3 of ethanol and diethyl ether, and then dried through vacuo (Wells, 1984). The yield is 35%, based on metal (Podson & King, 1945). Elemental analytical computation for the C8H16N8O10S2Mo: S, 10.00; C, 15.00; N, 17.50; H, 2.50%; illustrate that N, 17.51; C, 14.98; N, 17.51; H, 2.82; and AM(DMSO) 3 S cm2per mol (Greenwood & Earnshaw, 1997). W2O5L2(H2O)2.H2O (2) preparation (Anthony, 2007). This uses (NH4)2(WO4) and uses the same method applied in the first procedure (Peter, 2003). In this procedure, a bright yellow substance is isolated (Petricci et al, 2002). The yield is 50% metal based (Housecroft & Sharpe, 2005). The elemental analytical computation for C8H16N8O10S2W: H, 1.96; S, 7.85; C, 11.77; N, 13.73%, indicates that C, 11.62; S, 7.95; N, 13.77; H, 1.90%; and AM(DMSO) 2 S cm2per mol (Cotton et al, 1999). In analyzing the antimicrobial activity; the bacterial strains were cultured in the nutrient agar slants (De Vito et al, 2005). The bacteria strains are the S. aureaus and also the P. aeruginosa (Jansen, 2003). The fungal strains are also nurtured in dextrose agar plates (Bury, 1921). The fungal strains are C. albicans and A. niger (Petruccieta, 2002). Viable bacteria cells are then put on the nutrient agar plates and the fungal spores are put on the Sabouraud dextrose plates (Zumdahl, 2005). Free complexes and ligand 1, 4, 7 are dissolved in the DMSO3; and complex 8 is dissolved in measured H2O which has 100, 50, 10 and 20 mg/ml concentrations (Miessler & Tarr, 1999). The blank is DMSO in the saline buffer (Greenwood & Earnshaw, 1997). The bacteria plates and the fungal plates are incubated for duration of 36 hours and 72 hours respectively (Wilkinson, 1988). The activities of the compounds are approximated through measuring diameter of inhibition zone (Housecrost et al, 2005). The incubation temperature was recorded as approximately 27degrees Celsius (cotton & Simon, 2004). The results of this preparation clearly illustrate that, the first series metals indicate antimicrobial and anti-cancerous activities. The first transition metals are also good catalysts. This is because they have the ability to review oxidation state, or adsorb other substances, and hence activate them. For example, iron has the ability of speeding up the combination of hydrogen and nitrogen to produce ammonia, in the Haber reactions. Conclusion The M/H reaction systems illustrates interesting complexes source (Slerri, 2011). In the experiment, the ligand L- operates like a bidentate chelate in the prepared complexes with deprotonated oxygen and likely the amino nitrogen of position 6 of pyrimide ring acting as donor atoms (Harris & Bertolucci, 1989). Results illustrated in this research work represent initial study of chemistry of LH and also the biological activities of complexes (Cotton et al, 2004). References Anthony E. (2007). "Peñoles, UAM unveil pilot thiourea Au-Ag leaching plant - Mexico". Business News Americas. Beak, P. et al (1980). "Displacement of protomeric equilibriums by self-association: hydroxypyridine-pyridone and mercaptopyridine-thiopyridone isomer pairs". The Journal of Organic Chemistry. Bernd, M. et al (2002). "Thiourea and Thiourea Derivatives" Encyclopedia of Industrial Chemistry. Bury, C. (1921). "Langmuir's theory of the arrangement of electrons in atoms and molecules". J. Amer. Chem. Soc. 43 (7): 1602–1609. Chou, W. & Yang, K. (2008). 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